New Zebra ZD421 and ZD621 desktop label printers
In 2021, Zebra introduced their new ZD421 and ZD621 label printers, offering a variety of models including direct thermal, thermal transfer, healthcare, and ribbon cartridge. These versatile printers support a wide range of applications and are equipped with Zebra’s Print DNA software suite, making them easy to set up, operate, manage, and maintain both on-site and remotely.
The new Zebra ZD421 replaces the ZD420 and GK420
The Zebra ZD421 is the successor to the ZD420 and GK420 models, featuring advanced capabilities and enhanced security. Key improvements include a more intuitive user interface, a powerful new architecture, and a field-upgradeable wireless kit. The updated media guide and media handling designs simplify operation even further.
Product Comparison ZD421 vs. ZD420 and GK420
Best deals: Zebra ZD421 DIRECT THERMAL label printers
Best deals: Zebra ZD421 THERMAL TRANSFER label printers
The new Zebra ZD621 replaces the ZD620, ZD500, GX420 and GX430
Replacing the ZD620, ZD500, GX420, and GX430 models, the Zebra ZD621 offers premium features, maximum performance, and unmatched security. Available in healthcare and RFID models, the ZD621 builds on the legacy of Zebra’s ZD620 and GX-Series printers, providing next-generation, best-in-class features for hassle-free printing. Benefits include outstanding print quality, an innovative architecture for future adaptability, increased remote management capabilities, and an optional full-color LCD touch display with an intuitive menu.
Product Comparison ZD621 vs. ZD620 and GX420 / GX430
Best deals: Zebra printer ZD621 DIRECT THERMAL
Best deals: Zebra printer ZD621 THERMAL TRANSFER
Zebra ZD420 to ZD421 migration guide
For users upgrading from the ZD420 to the ZD421, here’s a handy guide to identify the right replacement part numbers for the discontinued ZD420 models.
| Zebra ZD420 model | Discontinued Part Number | Replacement Part Number | Zebra ZD421 model |
| Zebra ZD420t (cartridge) | ZD42042-C0E000EZ | ZD4A042-C0EM00EZ | Zebra ZD421t (cartridge) |
| Zebra ZD420t (cartridge) | ZD42042-C0EE00EZ | ZD4A042-C0EE00EZ | Zebra ZD421t (cartridge) |
| Zebra ZD420t (cartridge) | ZD42042-C0EW02EZ | ZD4A042-C0EW02EZ | Zebra ZD421t (cartridge) |
| Zebra ZD420d | ZD42042-D0E000EZ | ZD4A042-D0EM00EZ | Zebra ZD421d |
| Zebra ZD420d | ZD42042-D0EE00EZ | ZD4A042-D0EE00EZ | Zebra ZD421d |
| Zebra ZD420d | ZD42042-D0EW02EZ | ZD4A042-D0EW02EZ | Zebra ZD421d |
| Zebra ZD420t | ZD42042-T0E000EZ | ZD4A042-30EM00EZ | Zebra ZD421t |
| Zebra ZD420t | ZD42042-T0EE00EZ | ZD4A042-30EE00EZ | Zebra ZD421t |
| Zebra ZD420t | ZD42042-T0EW02EZ | ZD4A042-30EW02EZ | Zebra ZD421t |
| Zebra ZD420t (cartridge) | ZD42043-C0E000EZ | ZD4A043-C0EM00EZ | Zebra ZD421t (cartridge) |
| Zebra ZD420t (cartridge) | ZD42043-C0EE00EZ | ZD4A043-C0EE00EZ | Zebra ZD421t (cartridge) |
| Zebra ZD420t (cartridge) | ZD42043-C0EW02EZ | ZD4A043-C0EW02EZ | Zebra ZD421t (cartridge) |
| Zebra ZD420d | ZD42043-D0E000EZ | ZD4A043-D0EM00EZ | Zebra ZD421d |
| Zebra ZD420d | ZD42043-D0EE00EZ | ZD4A043-D0EE00EZ | Zebra ZD421d |
| Zebra ZD420d | ZD42043-D0EW02EZ | ZD4A043-D0EW02EZ | Zebra ZD421d |
| Zebra ZD420t | ZD42043-T0E000EZ | ZD4A043-30EM00EZ | Zebra ZD421t |
| Zebra ZD420t | ZD42043-T0EE00EZ | ZD4A043-30EE00EZ | Zebra ZD421t |
| Zebra ZD420t | ZD42043-T0EW02EZ | ZD4A043-30EW02EZ | Zebra ZD421t |
